SELL monoclonal antibody, clone DREG56
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Specification
Product Description
Mouse monoclonal antibody raised against native SELL.
Immunogen
Native purified SELL from PMA-activated human peripheral blood leukocytes.
Host
Mouse
Theoretical MW (kDa)
65-76
Reactivity
Human
Specificity
This antibody recognizes SELL, a 65-76 KDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells.
Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (2 ug/mL)
Immunohistochemistry
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Functional Study
Flow Cytometry
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Gene Info — SELL
Entrez GeneID
6402Gene Name
SELL
Gene Alias
CD62L, LAM-1, LAM1, LECAM1, LNHR, LSEL, LYAM1, Leu-8, Lyam-1, PLNHR, TQ1, hLHRc
Gene Description
selectin L
Gene Ontology
HyperlinkGene Summary
SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. [provided by RefSeq
Other Designations
Leu-8 antigen|leukocyte adhesion molecule-1|lymph node homing receptor|lymphocyte adhesion molecule 1
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Interactome
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Pathway
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Disease
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Publication Reference
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In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.
Killock DJ, Parsons M, Zarrouk M, Ameer-Beg SM, Ridley AJ, Haskard DO, Zvelebil M, Ivetic A.
The Journal of Biological Chemistry 2009 Jan; 284(13):8833.
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Critical role of Lck in L-selectin signaling induced by sulfatides engagement.
Xu T, Chen L, Shang X, Cui L, Luo J, Chen C, Ba X, Zeng X.
Journal of Leukocyte Biology 2008 Oct; 84(4):1192.
Application:WB-Ce, WB-Tr, Human, Jurkat cells.
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L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts.
Jutila MA, Kurk S, Jackiw L, Knibbs RN, Stoolman LM.
The Journal of Immunology 2002 Aug; 169(4):1768.
Application:Flow Cyt, WB-Ce, Human, Jurkat T cells, T lymphoblasts.
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Selectin blockade prevents antigen-induced late bronchial responses and airway hyperresponsiveness in allergic sheep.
Abraham WM, Ahmed A, Sabater JR, Lauredo IT, Botvinnikova Y, Bjercke RJ, Hu X, Revelle BM, Kogan TP, Scott IL, Dixon RA, Yeh ET, Beck PJ.
American Journal of Respiratory and Critical Care Medicine 1999 Apr; 159(4 Pt 1):1205.
Application:ELISA, Mouse, Mouse peritoneal ascites fluid.
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Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro.
Kishimoto TK, Warnock RA, Jutila MA, Butcher EC, Lane C, Anderson DC, Smith CW.
Blood 1991 Aug; 78(3):805.
Application:Func, Human, Mouse, HUVECs, L cells, Neutrophils.
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In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.
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