Calca monoclonal antibody, clone 4901
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Specification
Product Description
Mouse monoclonal antibody raised against native Calca.
Immunogen
Native purified rat Calca.
Host
Mouse
Reactivity
Human, Rat
Specificity
This antibody has been directly tested for reactivity in rat and human. It is expected that This antibody will react with most mammals. specific to Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested positive controls are dorsal root ganglia, pancreas and gut.
Form
Liquid
Purification
Protein G purification
Isotype
IgG2a
Recommend Usage
Immunocytochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 0.1 mg/mL BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunocytochemistry
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Gene Info — Calca
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Publication Reference
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New therapeutic target in primary headaches - blocking theCGRP receptor.
Edvinsson L.
Expert Opinion on Therapeutic Targets 2003 Jun; 7(3):377.
Application：IF, Human, Human brains.
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Monoclonal antibody to rat alpha-CGRP: production, characterization, and in vivo immunoneutralization activity.
Wong HC, Tache Y, Lloyd KC, Yang H, Sternini C, Holzer P, Walsh JH.
Hybridoma 1993 Feb; 12(1):93.
Application：IF, Dog, Rat, Pancreas, Small intestine.
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Calcitonin gene-related peptide is a potent vasodilator.
Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I.
Nature 1985 Jan; 313(5997):54.
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New therapeutic target in primary headaches - blocking theCGRP receptor.
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