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Last updated: 2017/12/10
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LGR4 monoclonal antibody, clone 6G8.B3.G5.C3

  • Catalog # : MAB8166
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of LGR4 .
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human LGR4 .
  • Host:
  • Mouse
  • Reactivity:
  • Chimpanzee, Human, Macaque
  • Form:
  • Liquid
  • Recommend Usage:
  • ELISA (1:20000-1:100000)
    Western Blot (1:500-1:3000)
    Immunohistochemistry (5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of LGR4 monoclonal antibody, clone 6G8.B3.G5.C3 (Cat # MAB8166) was used diluted to 5 ug/mL to detect LGR4 staining at the membrane of cells in various human tissues.
    A. Brain cerebellum.
    B. Pancreas islet.
    Strongly positive staining is noted in subsets of cells within the islets of Langerhans. Moderately positive staiing was observed in Purkinje and Golgi neurons of the cerebellum, adrenal medulla, neuroendocrine cells, hepatocytes, lung macrophages, seminiferous tubules and Leydig cells of the testis. Faintly to moderately positive staining was also observed in cardiac myocytes and renal tubules, granulocytes, and subsets of lymphocytes. Some elastin background staining is noted. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.
    Personal communication, Andrew Elston, Lifespan Biosc
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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  • Gene Information
  • Gene Name:
  • LGR4
  • Gene Alias:
  • GPR48
  • Gene Description:
  • leucine-rich repeat-containing G protein-coupled receptor 4
  • Gene Summary:
  • G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM
  • Other Designations:
  • G protein-coupled receptor 48,G-protein-coupled receptor 48
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