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Last updated: 2016/12/4
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TPSAB1 monoclonal antibody, clone 3H2643

  • Catalog # : MAB8065
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native TPSAB1.
  • Immunogen:
  • Native purified TPSAB1 from human lung tissue.
  • Host:
  • Mouse
  • Reactivity:
  • Chicken, Dog, Human, Monkey
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining in human lung with TPSAB1 monoclonal antibody, clone 3H2643 (Cat # MAB8065).
  • ELISA
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 7177
  • Gene Name:
  • TPSAB1
  • Gene Alias:
  • MCP7,TPS1,TPS2,TPSB1
  • Gene Description:
  • tryptase alpha/beta 1
  • Gene Summary:
  • Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq
  • Other Designations:
  • lung tryptase,mast cell protease II,mast cell tryptase,pituitary tryptase,skin tryptase,tryptase 1,tryptase II,tryptase alpha II,tryptase beta 1,tryptase beta I,tryptase, alpha,tryptase-I,tryptase-III
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