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Western Blot

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

Gene Name

TPSAB1

Gene Alias

MCP7, TPS1, TPS2, TPSB1

Gene Description

tryptase alpha/beta 1

Omim ID

Gene Ontology

Gene Summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq

Other Designations

lung tryptase|mast cell protease II|mast cell tryptase|pituitary tryptase|skin tryptase|tryptase 1|tryptase II|tryptase alpha II|tryptase beta 1|tryptase beta I|tryptase, alpha|tryptase-I|tryptase-III