FCER1A monoclonal antibody, clone CRA2
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More Files
- More Functions
Flow Cytometry
FACS analysis of Chinese hamster ovary (CHO) transfectant cells expressing FCER1A (1 X 105) with FCER1A monoclonal antibody, clone CRA1 (Cat # MAB7943) and CRA2 antibodies by Indirect-immunostaining, using FITC-labeled secondary antibody.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant FCER1A.
Immunogen
Recombinant protein corresponding to human FCER1A.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Flow Cytometry
FACS analysis of Chinese hamster ovary (CHO) transfectant cells expressing FCER1A (1 X 105) with FCER1A monoclonal antibody, clone CRA1 (Cat # MAB7943) and CRA2 antibodies by Indirect-immunostaining, using FITC-labeled secondary antibody. -
Gene Info — FCER1A
Entrez GeneID
2205Gene Name
FCER1A
Gene Alias
FCE1A, FcERI
Gene Description
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Omim ID
147140Gene Ontology
HyperlinkGene Summary
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM
Other Designations
Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions.
Takai T, Yuuki T, Iwamoto-Yasue N, Okumura K, Ra C.
Bioscience, Biotechnology, and Biochemistry 2000 Sep; 64(9):1856.
Application：WB-Re, Recombinant protein.
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The alpha subunit of the human IgE receptor (FcERI) is sufficient for high affinity IgE binding.
Hakimi J, Seals C, Kondas JA, Pettine L, Danho W, Kochan J.
The Journal of Biological Chemistry 1990 Dec; 265(36):22709.
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A macrophage Fc gamma receptor and the mast cell receptor for IgE share an identical subunit.
Ra C, Jouvin MH, Blank U, Kinet JP.
Nature 1989 Oct; 341(6244):752.
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Epitope analysis and primary structures of variable regions of anti-human FcepsilonRI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions.
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