Itgb2 monoclonal antibody, clone M18/2
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Specification
Product Description
Rat monoclonal antibody raised againt native Itgb2.
Immunogen
Native purified Itgb2 from mouse cytotoxic T cell glycoproteins.
Host
Rat
Theoretical MW (kDa)
95
Reactivity
Mouse
Specificity
This antibody recognizes Itgb2 antigen (integrin beta2 subunit; beta 2 integrin), a 95 KDa type I transmembrane protein expressed on all leukocytes.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Flow Cytometry (1 ug/mL)
Functional Study
Immunohistochemistry
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
Functional Study
Blocking
Flow Cytometry
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Gene Info — Itgb2
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Publication Reference
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Neutrophil-selective CD18 silencing using RNA interference in vivo.
Cullere X, Lauterbach M, Tsuboi N, Mayadas TN.
Blood 2008 Apr; 111(7):3591.
Application：Flow Cyt, Mouse, Mouse peripheral blood leukocytes.
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Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation.
Varga G, Balkow S, Wild MK, Stadtbaeumer A, Krummen M, Rothoeft T, Higuchi T, Beissert S, Wethmar K, Scharffetter-Kochanek K, Vestweber D, Grabbe S.
Blood 2007 Jan; 109(2):661.
Application：Func, Mouse, Mouse dendritic cells.
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CD18 deficiency protects against multiple low-dose streptozotocin-induced diabetes.
Barlow SC, Langston W, Matthews KM, Chidlow JH Jr, Kevil CG.
The American Journal of Pathology 2004 Dec; 165(6):1849.
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Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization.
Sakurai E, Taguchi H, Anand A, Ambati BK, Gragoudas ES, Miller JW, Adamis AP, Ambati J.
Investigative Ophthalmology & Visual Science 2003 Jun; 44(6):2743.
Application：IHC-P, Mouse, Mouse eyes.
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Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1.
Abraham C, Miller J.
Journal of Immunology 2001 Nov; 167(9):5193.
Application：ELISA, Func, Mouse, T cells.
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Neutrophil-selective CD18 silencing using RNA interference in vivo.
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