Itgal monoclonal antibody, clone M17/4
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Specification
Product Description
Rat monoclonal antibody raised againt native Itgal.
Immunogen
Native purified Itgal from C57BL/6 mouse splenic secondary cytotoxic T lymphocytes.
Host
Rat
Theoretical MW (kDa)
180
Reactivity
Mouse
Specificity
This antibody reacts with Itgal (alpha-subunit of murine LFA-1), a180 KDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Form
Liquid
Purification
Protein-G affinity chromatography.
Isotype
IgG2a
Recommend Usage
Immunohistochemistry
Immunoprecipitation
Flow Cytometry (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Functional Study
Blocking
Flow Cytometry
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Gene Info — Itgal
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Publication Reference
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The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo.
Beyer M, Wang H, Peters N, Doths S, Koerner-Rettberg C, Openshaw PJ, Schwarze J.
Respiratory Research 2005 Jul; 6:70.
Application:Flow Cyt, Mouse, CD11c+, CD11c- CD8+ T cells.
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Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation.
Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S, Haslett C, Mutsaers SE, Laurent GJ.
The Journal of Experimental Medicine 2002 Dec; 196(11):1515.
Application:Blocking, Mouse, Macrophage-mesothelial cells.
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In situ demonstration of intraepithelial lymphocyte adhesion to villus microvessels of the small intestine.
Koseki S, Miura S, Fujimori H, Hokari R, Komoto S, Hara Y, Ogino T, Nagata H, Goto M, Hachimura S, Kaminogawa S, Ishii H.
International Immunology 2001 Sep; 13(9):1165.
Application:Flow Cyt, Mouse, Mouse lymphocytes.
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Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice.
Papayannopoulou T, Priestley GV, Nakamoto B, Zafiropoulos V, Scott LM, Harlan JM.
Blood 2001 Mar; 97(5):1282.
Application:Injection, Recombinant protein.
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Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice.
Yung R, Powers D, Johnson K, Amento E, Carr D, Laing T, Yang J, Chang S, Hemati N, Richardson B.
The Journal of Clinical Investigation 1996 Jun; 97(12):2866.
Application:ELISA, Flow Cyt, Mouse, D10.G4.1 cells.
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The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo.
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