IGFBP3 monoclonal antibody, clone SBH10
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant IGFBP3.
Immunogen
Recombinant protein corresponding to human IGFBP3.
Host
Mouse
Reactivity
Human
Form
Lyophilized
Isotype
IgG2a
Recommend Usage
ELISA (0.5-1 ug/mL)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IGFBP3
Entrez GeneID
3486Protein Accession#
P17936Gene Name
IGFBP3
Gene Alias
BP-53, IBP3
Gene Description
insulin-like growth factor binding protein 3
Omim ID
146732Gene Ontology
HyperlinkGene Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
IGF-binding protein 3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Nuclear export and mitochondrial and endoplasmic reticulum localization of IGF-binding protein 3 regulate its apoptotic properties.
Paharkova-Vatchkova V, Lee KW.
Endocrine-Related Cancer 2010 Mar; 17(2):293.
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Randomized GH trial with two different dosages in combination with a GnRH analogue in short small for gestational age children: effects on metabolic profile and serum GH, IGF1, and IGFBP3 levels.
van der Kaay D, Bakker B, van der Hulst F, Mul D, Mulder J, Schroor E, van Elswijk D, Rowaan I, Willeboer M, de Ridder M, Hokken-Koelega A.
European Journal of Endocrinology 2010 Feb; 162(5):887.
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Nuclear export and mitochondrial and endoplasmic reticulum localization of IGF-binding protein 3 regulate its apoptotic properties.
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