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Last updated: 2016/12/4
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TNNI1 monoclonal antibody, clone 12F10

  • Catalog # : MAB7795
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length native TNNI1.
  • Immunogen:
  • Native purified full length human TNNI1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Troponin I from human skeletal muscle. Cross-reaction of this with cardiac troponin I is less then 0.05%.
  • Form:
  • Liquid
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • ELISA
  • Application Image
  • Western Blot
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 7135
  • Gene Name:
  • TNNI1
  • Gene Alias:
  • DKFZp451O223,SSTNI,TNN1
  • Gene Description:
  • troponin I type 1 (skeletal, slow)
  • Gene Summary:
  • Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000033877,OTTHUMP00000033910,slow-twitch skeletal troponin I,troponin I, skeletal, slow
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