ORC1L monoclonal antibody, clone ORC1 7F6/1
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Specification
Product Description
Mouse monoclonal antibody raised against ORC1L.
Immunogen
Full length human ORC1L.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:1250-1:2500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
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Gene Info — ORC1L
Entrez GeneID
4998Gene Name
ORC1L
Gene Alias
HSORC1, ORC1, PARC1
Gene Description
origin recognition complex, subunit 1-like (yeast)
Omim ID
601902Gene Ontology
HyperlinkGene Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq
Other Designations
OTTHUMP00000009797|OTTHUMP00000009798|origin recognition complex 1|origin recognition complex, subunit 1|origin recognition complex, subunit 1, S. cerevisiae, homolog-like|replication control protein 1
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Interactome
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Pathway
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Publication Reference
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Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.
Burke TW, Cook JG, Asano M, Nevins JR.
The Journal of Biological Chemistry 2001 May; 276(18):15397.
Application:WB-Tr, Human, C33A cells.
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Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.
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