HLA-DRB1 monoclonal antibody, clone DA2
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Specification
Product Description
Mouse monoclonal antibody raised against native HLA-DRB1.
Immunogen
Native purified HLA-DRB1 from the membranes of LKT cells.
Host
Mouse
Reactivity
Human
Specificity
HLA-DR beta chain 1. All DR and DP except DR7. Not specific to humans. WB: Predicted molecular weight: 30 KDa (unprocessed precursor). Epitope is the 1st domain, monomorphic.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — HLA-DRB1
Entrez GeneID
3123Gene Name
HLA-DRB1
Gene Alias
DRB1, FLJ76359, HLA-DR1B, HLA-DRB, HLA-DRB1*, SS1
Gene Description
major histocompatibility complex, class II, DR beta 1
Gene Ontology
HyperlinkGene Summary
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq
Other Designations
HLA class II antigen beta chain|HLA class II histocompatibility antigen, DR-1 beta chain|HLA-DR-beta 1|MHC class II HLA-DR beta 1 chain|MHC class II HLA-DR-beta cell surface glycoprotein|MHC class II antigen HLA-DR13|human leucocyte antigen DRB1|leucocyte
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Interactome
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Publication Reference
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Monoclonal antibodies to HLA--DRw determinants.
Brodsky FM, Parham P, Bodmer WF.
Tissue Antigens 1980 Jul; 16(1):30.
Application:SDS-PAGE, Human, IBW4, PGF, LKT, Priess, IDF, WT52, Arnt, Mann, Madura T, Herluff, WT46, GFF, Brel cells, Lymphocytes.
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Monoclonal antibodies for analysis of the HLA system.
Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer WF.
Immunological Reviews 1979 Oct; 47:3.
Application:SDS-PAGE, Recombinant protein.
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Monoclonal antibodies to HLA--DRw determinants.
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