FAT1 monoclonal antibody, clone FAT-1 3D7/1
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Specification
Product Description
Mouse monoclonal antibody raised against FAT1.
Immunogen
Cytoplasmic domain of drosphila FAT1.
Host
Mouse
Reactivity
Fruit fly
Specificity
FAT (Fat-1). Expected to cross-react with Rat (85% identity with immunogen) and Chimpanzee (92% identity with immunogen) due to sequence homology. Predicted molecular weight 506 KDa.
Form
Liquid
Isotype
IgM
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — FAT1
Entrez GeneID
2195Gene Name
FAT1
Gene Alias
CDHF7, FAT, ME5, hFat1
Gene Description
FAT tumor suppressor homolog 1 (Drosophila)
Omim ID
600976Gene Ontology
HyperlinkGene Summary
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq
Other Designations
FAT tumor suppressor 1|cadherin ME5|cadherin family member 7|cadherin-related tumor suppressor
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Interactome
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Disease
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Publication Reference
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Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila.
Bryant PJ, Huettner B, Held LI Jr, Ryerse J, Szidonya J.
Developmental Biology 1988 Oct; 29(2):541.
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Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila.
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