Mouse monoclonal antibody raised against synthetic peptide of ERBB4.
A synthetic peptide corresponding to amino acids 1250-1264 of human ERBB4.
HER4 (HFR1). Predicted to react with Rat (100% identity with immunogen) and Chicken (100% identity with immunogen) due to sequence homology.T his antibody is useful for Western blot analysis (predicted molecular weight 147 KDa). There may be some non-specific staining below 50 KDa.
Western Blot (3 ug/mL) The optimal working dilution should be determined by the end user.
In PBS (1 mg/mL BSA)
Store at 4°C for short term. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq