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Last updated: 2017/1/15
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ERBB4 monoclonal antibody, clone HFR1

  • Catalog # : MAB7170
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of ERBB4.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 1250-1264 of human ERBB4.
  • Sequence:
  • RSTLQHPDYLQEYST
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • HER4 (HFR1). Predicted to react with Rat (100% identity with immunogen) and Chicken (100% identity with immunogen) due to sequence homology.T his antibody is useful for Western blot analysis (predicted molecular weight 147 KDa). There may be some non-specific staining below 50 KDa.
  • Form:
  • Liquid
  • Isotype:
  • IgG2b
  • Recommend Usage:
  • Western Blot (3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (1 mg/mL BSA)
  • Storage Instruction:
  • Store at 4°C for short term. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot of ERBB4 detected in human brain lysates using ERBB4 monoclonal antibody, clone HFR1 (Cat # MAB7170) at 2.0 ug/mL .
  • Immunohistochemistry
  • Immunoprecipitation
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 2066
  • Gene Name:
  • ERBB4
  • Gene Alias:
  • HER4,MGC138404,p180erbB4
  • Gene Description:
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
  • Gene Summary:
  • This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
  • Other Designations:
  • avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4,receptor tyrosine-protein kinase erbB-4,tyrosine kinase-type cell surface receptor HER4,v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4,v-erb-a erythroblastic leukemia v
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