SIGLEC1 monoclonal antibody, clone HSn 7D2
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Specification
Product Description
Mouse monoclonal antibody raised against SIGLEC1.
Immunogen
Full length human SIGLEC1.
Host
Mouse
Reactivity
Human
Specificity
Sialoadhesin (HSn 7D2). Theoretical Molecular Weight: 183 KDa. The epitope is located within domains 1-4.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
Radioimmunoassay
Flow Cytometry
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Gene Info — SIGLEC1
Entrez GeneID
6614GeneBank Accession#
Q9BZZ2Gene Name
SIGLEC1
Gene Alias
CD169, DKFZp667F058, FLJ00051, FLJ00055, FLJ00073, FLJ00411, FLJ32150, SIGLEC-1, SN, dJ1009E24.1
Gene Description
sialic acid binding Ig-like lectin 1, sialoadhesin
Omim ID
600751Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000030124|sialic acid-binding immunoglobulin-like lectin 1|sialoadhesin
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Interactome
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Pathway
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Publication Reference
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Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR.
Blood 2001 Jan; 97(1):288.
Application：IEM, IHC-Fr, Human, Bone marrow, Colon, Livers, Lungs, Macrophages, Reactive lymph node, Spleen.
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The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone.
B Steiniger, P Barth, B Herbst, A Hartnell, P R Crocker.
Immunology 1997 Oct; 92(2):307.
Application：IHC-P, Human, Human spleen.
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Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations.
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