MUC1 monoclonal antibody, clone SM3
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Specification
Product Description
Mouse monoclonal antibody raised against native MUC1.
Immunogen
Native purified MUC1 from hydrogen fluoride deglycosylated milk mucin.
Host
Mouse
Reactivity
Human
Specificity
Reacts very little with normal tissue. Found to react with breast, colon and ovarian carcinomas and adinocarcinoma. SM3 recognizes the under-glycosylated form of MUC1 and is therefore tumour specific.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
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Gene Info — MUC1
Entrez GeneID
4582Gene Name
MUC1
Gene Alias
CD227, EMA, H23AG, MAM6, PEM, PEMT, PUM
Gene Description
mucin 1, cell surface associated
Omim ID
158340Gene Ontology
HyperlinkGene Summary
This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. [provided by RefSeq
Other Designations
DF3 antigen|H23 antigen|MUC-1/SEC|MUC-1/X|MUC1/ZD|OTTHUMP00000033787|OTTHUMP00000033790|OTTHUMP00000033795|breast carcinoma-associated antigen DF3|episialin|mucin 1|mucin 1, transmembrane|peanut-reactive urinary mucin|polymorphic epithelial mucin|tumor as
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Interactome
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Disease
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Publication Reference
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A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes.
Burchell J, Taylor-Papadimitriou J, Boshell M, Gendler S, Duhig T.
International Journal of Cancer 1989 Oct; 44(4):691.
Application:ELISA, Peptide.
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Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.
Burchell J, Gendler S, Taylor-Papadimitriou J, Girling A, Lewis A, Millis R, Lamport D.
Cancer Research 1987 Oct; 47(20):5476.
Application:IHC-P, IP, WB-Re, Human, Human breast tissues, Purified proteins.
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A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes.
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