ICOS monoclonal antibody, clone ANC6C6-A3
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant ICOS.
Immunogen
A mixture of human HPB-MLT cells and recombinant human ICOS-muIg.
Host
Mouse
Reactivity
Human
Specificity
Antibody ANC6C6 blocks binding of recombinant CD275-muIg to CD278.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Enzyme Immunoassay
Flow Cytometry
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Gene Info — ICOS
Entrez GeneID
29851Gene Name
ICOS
Gene Alias
AILIM, CD278, MGC39850
Gene Description
inducible T-cell co-stimulator
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq
Other Designations
activation-inducible lymphocyte immunomediatory molecule|inducible costimulator
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules.
Ling V, Wu PW, Miyashiro JS, Marusic S, Finnerty HF, Collins M.
The Journal of Immunology 2001 Jun; 166(12):7300.
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ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement.
Riley JL, Blair PJ, Musser JT, Abe R, Tezuka K, Tsuji T, June CH.
The Journal of Immunology 2001 Apr; 166(8):4943.
Application:Flow Cyt, Human, CD4 T cells.
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Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor.
Ling V, Wu PW, Finnerty HF, Bean KM, Spaulding V, Fouser LA, Leonard JP, Hunter SE, Zollner R, Thomas JL, Miyashiro JS, Jacobs KA, Collins M.
Journal of Immunology 2000 Feb; 164(4):1653.
Application:Flow Cyt, Mouse, COS cells, Splenocytes.
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Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules.
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