TNFSF4 monoclonal antibody, clone ANC10G1
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Specification
Product Description
Mouse monoclonal antibody raised against TNFSF4.
Immunogen
A mixture of human HUVEC and recombinant protein of human TNFSF4.
Host
Mouse
Reactivity
Human
Specificity
Antibody ANC10G1 blocks binding of Recombinant CD134 to CD134L on HUVEC.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Enzyme Immunoassay
Flow Cytometry
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Gene Info — TNFSF4
Entrez GeneID
7292Gene Name
TNFSF4
Gene Alias
CD134L, CD252, GP34, OX-40L, OX4OL, TXGP1
Gene Description
tumor necrosis factor (ligand) superfamily, member 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq
Other Designations
CD134 ligand|OTTHUMP00000032704|OX40 antigen ligand|OX40 ligand|glycoprotein 34 kd|tax-transcriptionally activated glycoprotein 1 (34kD)
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Pathway
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Disease
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Publication Reference
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The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo.
Yuan X, Salama AD, Dong V, Schmitt I, Najafian N, Chandraker A, Akiba H, Yagita H, Sayegh MH.
The Journal of Immunology 2003 Mar; 170(6):2949.
Application:ELISPOT, Flow Cyt, Rat, Spleen cells, Splenocytes.
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Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses.
Taraban VY, Rowley TF, O'Brien L, Chan HT, Haswell LE, Green MH, Tutt AL, Glennie MJ, Al-Shamkhani A.
European Journal of Immunology 2002 Dec; 32(12):3617.
Application:Added, Recombinant protein.
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Association of the CD134/CD134L costimulatory pathway with acute rejection of small bowel allograft.
Tian L, Guo W, Yuan Z, Lui VC, Chan JK, Yagita H, Akiba H, Dallman M, Tam PK.
Transplantation 2002 Jul; 74(1):133.
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The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo.
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