SELE monoclonal antibody, clone HAE-1f
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Specification
Product Description
Mouse monoclonal antibody raised against native SELE.
Immunogen
Native purified SELE from TNF activated HUVEC.
Host
Mouse
Reactivity
Human
Specificity
Antibody HAE-1f blocks the function of CD62E.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — SELE
Entrez GeneID
6401Gene Name
SELE
Gene Alias
CD62E, ELAM, ELAM1, ESEL, LECAM2
Gene Description
selectin E
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq
Other Designations
OTTHUMP00000032745|endothelial adhesion molecule 1|leukocyte endothelial cell adhesion molecule 2
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Interactome
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Pathway
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Disease
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Publication Reference
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L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity.
Tu L, Chen A, Delahunty MD, Moore KL, Watson SR, McEver RP, Tedder TF.
Journal of Immunology 1996 Nov; 157(9):3995.
Application:ELISA, Flow Cyt, Monkey, Mouse, 300.19 cells, COS cells.
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A single amino acid residue can determine the ligand specificity of E-selectin.
Kogan TP, Revelle BM, Tapp S, Scott D, Beck PJ.
The Journal of Biological Chemistry 1995 Jun; 270(23):14047.
Application:ELISA, Monkey, COS-1 cells, Recombinant protein.
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L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity.
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