CD46 monoclonal antibody, clone 169-1-E4.3
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Specification
Product Description
Mouse monoclonal antibody raised against CD46.
Immunogen
A mixture of human PBL and EBV transformed LCL.
Host
Mouse
Reactivity
Human
Specificity
Antibody 169-1-E4.3 does not block MCP function (3).
Form
Liquid
Isotype
IgG2a
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — CD46
Entrez GeneID
4179Gene Name
CD46
Gene Alias
MCP, MGC26544, MIC10, TLX, TRA2.10
Gene Description
CD46 molecule, complement regulatory protein
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD46 antigen, complement regulatory protein|OTTHUMP00000034577|OTTHUMP00000034622|OTTHUMP00000034623|OTTHUMP00000034624|OTTHUMP00000034625|OTTHUMP00000034626|OTTHUMP00000034706|antigen identified by monoclonal antibody TRA-2-10|complement membrane cofacto
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Interactome
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Pathway
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Disease
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Publication Reference
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Improved treatment of sudden hearing loss by specific fibrinogen aphaeresis.
Ullrich H, Kleinjung T, Steffens T, Jacob P, Schmitz G, Strutz J.
Journal of Clinical Apheresis 2004 Jul; 19(2):71.
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A functional analysis of recombinant soluble CD46 in vivo and a comparison with recombinant soluble forms of CD55 and CD35 in vitro.
Christiansen D, Milland J, Thorley BR, McKenzie IF, Loveland BE.
European Journal of Immunology 1996 Mar; 26(3):578.
Application：WB-Re, Recombinant protein.
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Improved treatment of sudden hearing loss by specific fibrinogen aphaeresis.
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