ITGB4 monoclonal antibody, clone UMA9
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB4.
Immunogen
Native purified ITGB4 from human squamous cell carcinoma (UM-SCC-1).
Host
Mouse
Reactivity
Human
Specificity
Partially blocks laminin binding.
Form
Liquid
Isotype
IgG2a
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ITGB4
Entrez GeneID
3691Gene Name
ITGB4
Gene Alias
CD104
Gene Description
integrin, beta 4
Gene Ontology
HyperlinkGene Summary
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD104 antigen|GP150|integrin beta 4|integrin beta-4 subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.
Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG.
The EMBO Journal 1995 Sep; 14(18):4470.
Application:IF, IP, KA, WB-Ce, WB-Re, Human, Rat, 804G, A-431 cells, Recombinant proteins.
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The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4.
Van Waes C, Kozarsky KF, Warren AB, Kidd L, Paugh D, Liebert M, Carey TE.
Cancer Research 1991 May; 51(9):2395.
Application:IP, RIA, Human, Human primary neonatal keratinocytes, UM-Fibro-83, UM-SCC-38, UM-SCC-83 cells.
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Altered expression in squamous carcinoma cells of an orientation restricted epithelial antigen detected by monoclonal antibody A9.
Kimmel KA, Carey TE.
Cancer Research 1986 Jul; 46(7):3614.
Application:ICC, IHC-Fr, Human, Human skin, MeWo, SK-MEL-28, SK-OV-3, UM-PAd-1, UM-SCC-1, UM-SCC-13, WI-38 cells.
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Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.
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