CD29 monoclonal antibody, clone 4B7R
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Specification
Product Description
Mouse monoclonal antibody raised against CD29.
Immunogen
Human ocular melanoma cell line, V+B2
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes the CD29 integrin subunit
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ITGB1
Entrez GeneID
3688Gene Name
ITGB1
Gene Alias
CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB
Gene Description
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Omim ID
135630Gene Ontology
HyperlinkGene Summary
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019420|OTTHUMP00000046253|OTTHUMP00000063731|OTTHUMP00000063732|OTTHUMP00000063733|fibronectin receptor beta subunit|integrin VLA-4 beta subunit|integrin beta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B.
PLoS One 2008 Mar; 3(3):e1708.
Application:Func, Human, Human T cells.
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Anti-CD28 has a potent adjuvant effect on the antibody response to soluble antigens mediated through CTLA-4 by-pass.
Carlring J, Barr TA, Buckle AM, Heath AW.
European Journal of Immunology 2003 Jan; 33(1):135.
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Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.
Kariv I, Truneh A, Sweet RW.
Journal of Immunology 1996 Jul; 157(1):29.
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Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.
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