ITGA2B monoclonal antibody, clone 96.2C1
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGA2B.
Immunogen
Native purified ITGA2B from human PBL.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Flow Cytometry
5 X 105 ficoll prepared human peripheral blood lymphocytes were washed and preincubated 5 minutes with 20 uL of 250 ug/mL human IgG (To block non specific binding) after which they were incubated 45 minutes on ice with 80 uL of ITGA2B monoclonal antibody, clone 96.2C1 (Cat # MAB6940) at 10 ug/mL. Cells were washed twice and incubated with Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. A net 17% sub population of the cells stained positive with a mean shift of 2.5 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration. -
Gene Info — ITGA2B
Entrez GeneID
3674Gene Name
ITGA2B
Gene Alias
CD41, CD41B, GP2B, GPIIb, GTA, HPA3
Gene Description
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene Ontology
HyperlinkGene Summary
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin alpha 2b|platelet fibrinogen receptor, alpha subunit|platelet-specific antigen BAK
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