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Last updated: 2016/12/4
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ITGA2B monoclonal antibody, clone 96.2C1

  • Catalog # : MAB6940
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGA2B.
  • Immunogen:
  • Native purified ITGA2B from human PBL.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
  • Storage Instruction:
  • Store at 4°C.
  • Applications
  • Flow Cytometry
  • Flow Cytometry
  • 5 X 105 ficoll prepared human peripheral blood lymphocytes were washed and preincubated 5 minutes with 20 uL of 250 ug/mL human IgG (To block non specific binding) after which they were incubated 45 minutes on ice with 80 uL of ITGA2B monoclonal antibody, clone 96.2C1 (Cat # MAB6940) at 10 ug/mL. Cells were washed twice and incubated with Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed by FACS. A net 17% sub population of the cells stained positive with a mean shift of 2.5 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 3674
  • Gene Name:
  • ITGA2B
  • Gene Alias:
  • CD41,CD41B,GP2B,GPIIb,GTA,HPA3
  • Gene Description:
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Gene Summary:
  • ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
  • Other Designations:
  • integrin alpha 2b,platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK
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