IL2RB monoclonal antibody, clone 9A2 (DU-2)
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Specification
Product Description
Mouse monoclonal antibody raised against native IL2RB.
Immunogen
Native purified IL2RB from YT-1 acute human leukemia cells.
Host
Mouse
Reactivity
Human
Specificity
Antibody 9A2 (DU-2) inhibits binding of IL-2 to IL-2R beta (CD122).
Form
Liquid
Isotype
IgG2a, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — IL2RB
Entrez GeneID
3560Gene Name
IL2RB
Gene Alias
CD122, P70-75
Gene Description
interleukin 2 receptor, beta
Omim ID
146710Gene Ontology
HyperlinkGene Summary
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq
Other Designations
CD122 antigen|OTTHUMP00000028799|high affinity IL-2 receptor beta subunit|interleukin 2 receptor beta
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Interactome
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Publication Reference
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The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.
Goldsmith MA, Xu W, Amaral MC, Kuczek ES, Greene WC.
The Journal of Biological Chemistry 1994 May; 269(20):14698.
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A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor.
Fung MR, Scearce RM, Hoffman JA, Peffer NJ, Hammes SR, Hosking JB, Schmandt R, Kuziel WA, Haynes BF, Mills GB, et al..
Journal of Immunology 1991 Aug; 147(4):1253.
Application:Func, IP, KA, Human, Mouse, Baf cells, Human lymphoblasts, HUT 102, Jurkat, MT-1, YT-1 cells.
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The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.
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