ICAM1 monoclonal antibody, clone 8.4A6
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Specification
Product Description
Mouse monoclonal antibody raised against native ICAM1.
Immunogen
Native purified ICAM1 from human endothelial cells.
Host
Mouse
Reactivity
Human
Specificity
Antibody 8.4A6 inhibits CD54 binding to LFA-1.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ICAM1
Entrez GeneID
3383Gene Name
ICAM1
Gene Alias
BB2, CD54, P3.58
Gene Description
intercellular adhesion molecule 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq
Other Designations
cell surface glycoprotein P3.58|human rhinovirus receptor|intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer. Correlation with binding to LFA-1.
Reilly PL, Woska JR Jr, Jeanfavre DD, McNally E, Rothlein R, Bormann BJ.
Journal of Immunology 1995 Jul; 155(2):529.
Application:IP, WB-Ce, Human, A-549 cells, Purified proteins.
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The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site.
Berendt AR, McDowall A, Craig AG, Bates PA, Sternberg MJ, Marsh K, Newbold CI, Hogg N.
Cell 1992 Jan; 68(1):71.
Application:Func, Human, Monkey, COS cells, Erythrocytes, LFA-1 cells.
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The native structure of intercellular adhesion molecule-1 (ICAM-1) is a dimer. Correlation with binding to LFA-1.
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