ENG monoclonal antibody, clone SN6/N1-3A1
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Specification
Product Description
Mouse monoclonal antibody raised against native ENG.
Immunogen
Native purified ENG from human B-lineage leukemia cells.
Host
Mouse
Reactivity
Human
Specificity
Antibody SN6 will augment binding of TGF-b1 to CD105 expressing leukemia cells.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ENG
Entrez GeneID
2022Gene Name
ENG
Gene Alias
CD105, END, FLJ41744, HHT1, ORW, ORW1
Gene Description
endoglin
Gene Ontology
HyperlinkGene Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD105 antigen|OTTHUMP00000022221|Osler-Rendu-Weber syndrome 1
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Interactome
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Disease
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Publication Reference
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Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massague J, Letarte M.
The Journal of Biological Chemistry 1992 Sep; 267(27):19027.
Application:IP, Human, Monkey, COS-M6 cells, HUVECs.
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Efficient transplantation of human non-T-leukemia cells into nude mice and induction of complete regression of the transplanted distinct tumors by ricin A-chain conjugates of monoclonal antibodies SN5 and SN6.
Hara H, Luo Y, Haruta Y, Seon BK.
Cancer Research 1988 Aug; 48(16):4673.
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Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
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