CTLA4 monoclonal antibody, clone ANC152.2/8H5
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More Files
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Flow Cytometry
CTLA4 monoclonal antibody, clone ANC152.2/8H5 (Cat # MAB6927) blocked the binding of recombinant CTLA4-muIg fusion protein/R-PE conjugate to CD80 and CD86 expressed on human Raji cells.
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Specification
Product Description
Mouse monoclonal antibody raised against CTLA4.
Immunogen
A mixture of stimulated human PBL's and human CTLA4 Ig fusion protein.
Host
Mouse
Reactivity
Human
Specificity
MAB6927 blocks binding of CD152 (CTLA-4) Ig fusion protein to its CD80/CD86 receptor, and has been reported to modulate suppressive function of human T Regulatory cells in Vitro. It can bind to intracellular CD152 in fixed permeabolized cells. The F(ab')2 form has been used to inhibit proliferation of activated T cells in vitro in a cholera toxin model.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Enzyme Immunoassay
Flow Cytometry
CTLA4 monoclonal antibody, clone ANC152.2/8H5 (Cat # MAB6927) blocked the binding of recombinant CTLA4-muIg fusion protein/R-PE conjugate to CD80 and CD86 expressed on human Raji cells. -
Gene Info — CTLA4
Entrez GeneID
1493Gene Name
CTLA4
Gene Alias
CD152, CELIAC3, CTLA-4, GSE, IDDM12
Gene Description
cytotoxic T-lymphocyte-associated protein 4
Gene Ontology
HyperlinkGene Summary
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq
Other Designations
OTTHUMP00000163781|cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
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Interactome
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Pathway
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Disease
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Publication Reference
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CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.
Zheng Y, Manzotti CN, Liu M, Burke F, Mead KI, Sansom DM.
Journal of Immunology 2004 Mar; 172(5):2778.
Application：Flow Cyt, Func, Human, Human monocytes.
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Activated self-MHC-reactive T cells have the cytokine phenotype of Th3/T regulatory cell 1 T cells.
Kitani A, Chua K, Nakamura K, Strober W.
Journal of Immunology 2000 Jul; 165(2):691.
Application：Blocking, Human, Human T cells.
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CTLA-4: a negative regulator of autoimmune disease.
Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA.
The Journal of Experimental Medicine 1996 Aug; 184(2):783.
Application：Func, Mouse, PLP139-151-primed lymph node cells.
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CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells.
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