CD36 monoclonal antibody, clone SMO
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Specification
Product Description
Mouse monoclonal antibody raised against native CD36.
Immunogen
Native purified CD36 from human tonsil cells/PBM.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgM
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C. Do not freeze.
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Applications
Flow Cytometry
5 X 105 ficoll prepared human peripheral blood lymphocytes were washed and preincubated 5 minutes with 20 m l of 250 mg/mL human IgG (To block non specific binding) after which they were incubated 45 minutes on ice with 80m l of CD36 monoclonal antibody, clone SMO (Cat # MAB6908) at a concentration of 5 mg/mL. Cells were washed twice and incubated with Goat anti-Mouse Ig/FITC, after which they were washed three times, fixed and analyzed using a BD FACstar plus. A net 16% sub population of the cells stained positive with a mean shift of 1.05 log10 fluorescent units when compared to a Mouse IgM negative control at a similar concentration. -
Gene Info — CD36
Entrez GeneID
948Gene Name
CD36
Gene Alias
CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
Gene Description
CD36 molecule (thrombospondin receptor)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
CD36 antigen|CD36 antigen (collagen type I receptor, thrombospondin receptor)|PAS-4 protein|cluster determinant 36|fatty acid translocase|glycoprotein IIIb|leukocyte differentiation antigen CD36|platelet glycoprotein IV|scavenger receptor class B, member
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Interactome
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Publication Reference
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CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.
Ren Y, Silverstein RL, Allen J, Savill J.
The Journal of Experimental Medicine 1995 May; 181(5):1857.
Application:Func, Human, Human neutrophils.
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CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes.
Oquendo P, Hundt E, Lawler J, Seed B.
Cell 1989 Jul; 58(1):95.
Application:IP, Monkey, C32, COS cells.
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Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.
Hogg N, MacDonald S, Slusarenko M, Beverley PC.
Immunology 1984 Dec; 53(4):753.
Application:Func, IF, IHC, IP, Human, Human monocytes, platelets.
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CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.
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