CD19 monoclonal antibody, clone BU12
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Specification
Product Description
Mouse monoclonal antibody raised against native CD19.
Immunogen
Native purified CD19 from human EB-4 Burkitt lymphoma cell line .
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Flow Cytometry
5 X 105 cultured Raji cells were washed and incubated 45 minutes on ice with 80 uL of CD19 monoclonal antibody, clone BU12 (Cat # MAB6901) at 10 ug/mL. Cells were washed twice and incubated with Goat anti-Mouse IgG/FITC, after which they were washed three times, fixed and analyzed using a BD FACstar plus. Cells stained positive with a mean shift of 1.58 log10 fluorescent units when compared to a Mouse IgG1 negative control at a similar concentration. -
Gene Info — CD19
Entrez GeneID
930Gene Name
CD19
Gene Alias
B4, MGC12802
Gene Description
CD19 molecule
Omim ID
107265Gene Ontology
HyperlinkGene Summary
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq
Other Designations
B-lymphocyte antigen CD19|CD19 antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin alpha 4/beta 1 and fibronectin.
Behr S, Schriever F.
The Journal of Experimental Medicine 1995 Nov; 182(5):1191.
Application:Func, Human, Human tonsil sections, Raji cells.
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The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity.
Fearon DT, Carter RH.
Annual Review of Immunology 1995 Jan; 13:127.
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Engaging CD19 or target of an antiproliferative antibody 1 on human B lymphocytes induces binding of B cells to the interfollicular stroma of human tonsils via integrin alpha 4/beta 1 and fibronectin.
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