Western blot from crude cell extracts of AGS (gastric adenocarcinoma) cells with MYC (phospho S62) monoclonal antibody, clone 33A12E10 (Cat # MAB6763). Lane 1 : Scrambled siRNA was introduced into the cells as a negative control. Lane 2 : Negative control siRNA from Qiagen was transfected. Lane 3 : siRNA for MYC was transfected. The data was provided by A. Khanna and Dr. J. Westermark of University of Tampere.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq