Abcc5 monoclonal antibody, clone M5I-10
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Specification
Product Description
Rat monoclonal antibody raised against partial recombinant Abcc5.
Immunogen
Recombinant protein corresponding to amino acids 1-38 of mouse Abcc5.
Host
Rat
Reactivity
Human, Mouse
Specificity
M5I-10 reacts with an internal epitope of MRP5 (ABCC5), an approximately 160 kD transmembrane protein that is related to the multidrug resistance protein MRP1. The monoclonal antibody also strongly reacts with the human MRP5 protein.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Immunohistochemistry (Frozen sections) (1:20)
Immunocytochemistry (1:20-1:50)
Wstern Blot (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum-free culture supernatant (0.7% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunocytochemistry
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Gene Info — Abcc5
Entrez GeneID
27416Gene Name
Abcc5
Gene Alias
2900011L11Rik, AI132311, Abcc5a, Abcc5b, MGC116567, Mrp5
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Gene Ontology
HyperlinkGene Summary
sub-family C (CFTR/MRP)
Other Designations
ATP-binding cassette, sub-family C (CFTR/MRP), member 5a|ATP-binding cassette, sub-family C (CFTR/MRP), member 5b|ATP-binding cassette, sub-family C, member 5|OTTMUSP00000031743|OTTMUSP00000031744
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Publication Reference
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Multidrug resistance-associated proteins 3, 4, and 5.
Borst P, de Wolf C, van de Wetering K.
Pflügers Archiv : European Journal of Physiology 2007 Feb; 453(5):661.
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The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH.
Molecular Cancer Therapeutics 2005 May; 4(5):855.
Application：WB-Tr, Human, HEK 293 cells.
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Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.
Reid G, Wielinga P, Zelcer N, De Haas M, Van Deemter L, Wijnholds J, Balzarini J, Borst P.
Molecular Pharmacology 2003 May; 63(5):1094.
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Multidrug resistance-associated proteins 3, 4, and 5.
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