SCN9A monoclonal antibody, clone S68-6
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant SCN9A.
Immunogen
Recombinant fusion protein corresponding to C-terminus amino acids 1751-1946 of human SCN9A.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
Detects ~230KDa. No cross-reactivity against other Nav channels.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1-10 ug/mL)
Immunohistochemistry (0.1-1.0 ug/mL)
Immunocytochemistry (0.1-1.0 ug/mL)
Immunofluorescence (1.0-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis in SCN9A transfected CHO cell with SCN9A monoclonal antibody, clone S68-6 (Cat # MAB6661).Immunohistochemistry
Immunohistochemical staining in mouse brain tissue with SCN9A monoclonal antibody, clone S68-6 (Cat # MAB6661).Immunocytochemistry
Immunofluorescence
Immunofluorescence staining in human hippocampus (A) and mouse back skin (B) with SCN9A monoclonal antibody, clone S68-6 (Cat # MAB6661).Immunoprecipitation
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Gene Info — SCN9A
Entrez GeneID
6335Protein Accession#
Q15858Gene Name
SCN9A
Gene Alias
ETHA, NE-NA, NENA, Nav1.7, PN1
Gene Description
sodium channel, voltage-gated, type IX, alpha subunit
Gene Ontology
HyperlinkGene Summary
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq
Other Designations
sodium channel, voltage-gated, type IX, alpha|sodium channel, voltage-gated, type IX, alpha polypeptide|voltage-gated sodium channel alpha subunit Nav1.7
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Interactome
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Disease
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Publication Reference
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Congenital long QT syndrome.
Crotti L, Celano G, Dagradi F, Schwartz PJ.
Orphanet Journal of Rare Diseases 2008 Jul; 3:18.
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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT.
Cell 2004 Oct; 119(1):19.
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Congenital long QT syndrome.
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