Western blot analysis of rat tissue (a blend of rat skeletal muscle, heart, brain, kidney, liver, lung, pancreas, testes, spleen, and thymus) mixed lysate with KCNQ4 monoclonal antibody, clone S43-6 (Cat # MAB6656).
Immunofluorescence staining in human hippocampus with KCNQ4 monoclonal antibody, clone S43-6 (Cat # MAB6656).
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
OTTHUMP00000009219,potassium channel KQT-like 4,potassium voltage-gated channel KQT-like protein 4