KCNQ1 monoclonal antibody, clone S37A-10
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of human cell line mixed lysate with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
Western Blot (Transfected lysate)
Western blot analysis in mink-KvLQT1 transfected CHO cell with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
Immunohistochemistry
Immunohistochemical staining of mouse brain tissue with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
Immunofluorescence
Immunofluorescence staining in human hippocampus with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant KCNQ1.
Immunogen
Recombinant fusion protein corresponding to amino acids 2-101 of human KCNQ1.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
Detects ~75KDa.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1-10 ug/mL)
Immunohistochemistry (0.1-1.0 ug/mL)
Immunocytochemistry (0.1-1.0 ug/mL)
Immunofluorescence (1.0-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of human cell line mixed lysate with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).Western Blot (Transfected lysate)
Western blot analysis in mink-KvLQT1 transfected CHO cell with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).Immunohistochemistry
Immunohistochemical staining of mouse brain tissue with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).Immunofluorescence
Immunofluorescence staining in human hippocampus with KCNQ1 monoclonal antibody, clone S37A-10 (Cat # MAB6654).Immunoprecipitation
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Gene Info — KCNQ1
Entrez GeneID
3784Protein Accession#
P51787Gene Name
KCNQ1
Gene Alias
ATFB1, FLJ26167, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS
Gene Description
potassium voltage-gated channel, KQT-like subfamily, member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
Jervell and Lange-Nielsen syndrome 1|kidney and cardiac voltage dependend K+ channel|long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1|slow delayed rectifier channel subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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Congenital long QT syndrome.
Crotti L, Celano G, Dagradi F, Schwartz PJ.
Orphanet Journal of Rare Diseases 2008 Jul; 3:18.
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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT.
Cell 2004 Oct; 119(1):19.
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Congenital long QT syndrome.
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