CACNA1H monoclonal antibody, clone S55-10
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant CACNA1H.
Immunogen
Recombinant fusion protein corresponding to amino acids 1019-1293 (II-III loop) of human CACNA1H.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
Detects ~260KDa. No cross-reactivity against Cav1.3.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1-10 ug/mL)
Immunohistochemistry (0.1-1.0 ug/mL)
Immunocytochemistry (0.1-1.0 ug/mL)
Immunofluorescence (1.0-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunofluorescence
Immunofluorescence staining in human hippocampus with CACNA1H monoclonal antibody, clone S55-10 (Cat # MAB6650).Immunoprecipitation
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Gene Info — CACNA1H
Entrez GeneID
8912Protein Accession#
O95180Gene Name
CACNA1H
Gene Alias
CACNA1HB, Cav3.2, EIG6, FLJ90484
Gene Description
calcium channel, voltage-dependent, T type, alpha 1H subunit
Omim ID
607904Gene Ontology
HyperlinkGene Summary
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq
Other Designations
calcium channel, voltage-dependent, T type, alpha 1Hb subunit|calcium channel, voltage-dependent, alpha 1H subunit|low-voltage-activated calcium channel alpha1 3.2 subunit|low-voltage-activated calcium channel alpha13.2 subunit|voltage dependent t-type ca
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Interactome
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Pathway
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Disease
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Publication Reference
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Congenital long QT syndrome.
Crotti L, Celano G, Dagradi F, Schwartz PJ.
Orphanet Journal of Rare Diseases 2008 Jul; 3:18.
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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT.
Cell 2004 Oct; 119(1):19.
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Congenital long QT syndrome.
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