PDIA3 monoclonal antibody, clone MaP.ERP57
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant PDIA3.
Immunogen
Recombinant protein corresponding to human PDIA3.
Host
Mouse
Reactivity
Bovine, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat
Specificity
Detects ~57KDa.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
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Gene Info — PDIA3
Entrez GeneID
2923Gene Name
PDIA3
Gene Alias
ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC
Gene Description
protein disulfide isomerase family A, member 3
Omim ID
602046Gene Ontology
HyperlinkGene Summary
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq
Other Designations
58 kDa microsomal protein|OTTHUMP00000041709|endoplasmic reticulum P58|glucose regulated protein, 58kDa|phospholipase C-alpha|protein disulfide isomerase-associated 3|protein disulfide-isomerase A3
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Interactome
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Pathway
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Disease
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Publication Reference
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Laminin β2 Gene Missense Mutation Produces Endoplasmic Reticulum Stress in Podocytes.
Chen YM, Zhou Y, Go G, Marmerstein JT, Kikkawa Y, Miner JH.
Journal of the American Society of Nephrology 2013 Jul; 24(8):1223.
Application：IF, Human, HEK293T cells.
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Consequences of ERp57 deletion on oxidative folding of obligate and facultative clients of the calnexin cycle.
Solda T, Garbi N, Hammerling GJ, Molinari M.
The Journal of Biological Chemistry 2006 Mar; 281(10):6219.
Application：WB-Ce, Mouse, Mouse fibroblasts.
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Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.
Tan P, Kropshofer H, Mandelboim O, Bulbuc N, Hammerling GJ, Momburg F.
The Journal of Immunology 2002 Feb; 168(4):1950.
Application：IP, WB-Tr, Human, 220.B*4402 cells.
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Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins.
Oliver JD, van der Wal FJ, Bulleid NJ, High S.
Science 1997 Jan; 275(5296):86.
Application：IP, Dog, Plant, Wheat germ lysate supplemented with canine pancreatic microsomes.
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Laminin β2 Gene Missense Mutation Produces Endoplasmic Reticulum Stress in Podocytes.
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