FKBP5 monoclonal antibody, clone Hi51B
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More Files
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Immunofluorescence
Immunofluorescence localization in normal MK cells shown in red.
Using with FKBP5 monoclonal antibody, clone Hi51B (Cat # MAB6633).
Courtesy of the Hospital Henri Mondor, France.
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of FKBP5.
Immunogen
A synthetic peptide corresponding to human FKBP5.
Host
Mouse
Reactivity
Dog, Hamster, Human, Mouse, Rabbit, Rat
Specificity
Detects an ~51KDa protein representing FKBP51 in cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.
Form
Liquid
Isotype
IgG
Recommend Usage
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide, 50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Immunofluorescence localization in normal MK cells shown in red.
Using with FKBP5 monoclonal antibody, clone Hi51B (Cat # MAB6633).
Courtesy of the Hospital Henri Mondor, France. -
Gene Info — FKBP5
Entrez GeneID
2289Gene Name
FKBP5
Gene Alias
FKBP51, FKBP54, MGC111006, P54, PPIase, Ptg-10
Gene Description
FK506 binding protein 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq
Other Designations
51 kDa FK506-binding protein 5|54 kDa progesterone receptor-associated immunophilin|FF1 antigen|FK506-binding protein 5|HSP90-binding immunophilin|OTTHUMP00000016268|T-cell FK506-binding protein|peptidylprolyl cis-trans isomerase|rotamase
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Interactome
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Disease
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Publication Reference
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3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z.
PNAS 2004 May; 101(22):8348.
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C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90.
Cheung-Flynn J, Roberts PJ, Riggs DL, Smith DF.
The Journal of Biological Chemistry 2003 May; 278(19):17388.
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A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins.
Davies TH, Ning YM, Sanchez ER.
The Journal of Biological Chemistry 2001 Dec; 277(7):4597.
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3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex.
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