HSP90AA1/HSP90AA2 monoclonal antibody, clone Hyb-K41220A
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More Files
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Western Blot
Western blot analysis from cell lysates with HSP90AA1/HSP90AA2 monoclonal antibody, clone Hyb-K41220A (Cat # MAB6631).
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant HSP90AA1/HSP90AA2.
Immunogen
Recombinant protein corresponding to human HSP90AA1/HSP90AA2.
Host
Mouse
Reactivity
Human, Rat, S. pombe, Yeast
Specificity
Detects 90kD proteins corresponding to the molecular mass of hsp90 alpha or beta.
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis from cell lysates with HSP90AA1/HSP90AA2 monoclonal antibody, clone Hyb-K41220A (Cat # MAB6631).Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSP90AA1
Entrez GeneID
3320Gene Name
HSP90AA1
Gene Alias
FLJ31884, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2
Gene Description
heat shock protein 90kDa alpha (cytosolic), class A member 1
Omim ID
140571Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM
Other Designations
heat shock 90kD protein 1, alpha|heat shock 90kD protein 1, alpha-like 4|heat shock 90kD protein, alpha-like 4|heat shock 90kDa protein 1, alpha
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Gene Info — HSP90AA2
Entrez GeneID
3324Gene Name
HSP90AA2
Gene Alias
HSP90ALPHA, HSPCA, HSPCAL3
Gene Description
heat shock protein 90kDa alpha (cytosolic), class A member 2
Omim ID
140575Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
Neckers L.
Trends in Molecular Medicine 2002 Apr; 8(4 Suppl):S55.
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Steroid receptor interactions with heat shock protein and immunophilin chaperones.
Pratt WB, Toft DO.
Endocrine Reviews 1997 Jun; 18(3):306.
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Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.
Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM.
PNAS 1994 Aug; 91(18):8324.
Application：WB-Ce, Human, Mouse, NIH/3T3, PC-3M cells.
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
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