HMOX1 monoclonal antibody, clone 1F12-A6
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of HMOX1.
Immunogen
A synthetic peptide corresponding to amino acids 1-30 of human HMOX1.
Host
Mouse
Reactivity
Bovine, Human, Mouse
Specificity
Detects a 32KDa protein, corresponding to the molecular mass of HO-1 on SDS Page immunoblots. Does not cross-react with HO-2
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis from recombinant HMOX1 protein with HMOX1 monoclonal antibody, clone 1F12-A6 (Cat # MAB6628).Immunohistochemistry
Immunocytochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HMOX1
Entrez GeneID
3162Gene Name
HMOX1
Gene Alias
HO-1, HSP32, bK286B10
Gene Description
heme oxygenase (decycling) 1
Omim ID
141250Gene Ontology
HyperlinkGene Summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq
Other Designations
OTTHUMP00000028925|heme oxygenase (decyclizing) 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis.
Brydun A, Watari Y, Yamamoto Y, Okuhara K, Teragawa H, Kono F, Chayama K, Oshima T, Ozono R.
Hypertension Research 2007 Apr; 30(4):341.
Application:WB-Ce, Human, Human PBMCs.
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Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling.
Yet SF, Layne MD, Liu X, Chen YH, Ith B, Sibinga NE, Perrella MA.
FASEB Journal 2003 Sep; 17(12):1759.
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Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency.
Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S.
The Journal of Clinical Investigation 1999 Jan; 103(1):129.
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Reduced expression of heme oxygenase-1 in patients with coronary atherosclerosis.
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