HSP90B1 monoclonal antibody, clone H9010
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of heat shock HeLa lysate with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618).
Western Blot (Cell lysate)
Western blot analysis form cell lines extracts with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618).
Immunohistochemistry
Immunochemical staining of human colon cancer with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618) at 100,000 fold dilution.
Immunofluorescence
Immunofluorescence staining of mouse colon (A) and human colon cancer (B) with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618) at 100,000 fold dilution.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant HSP90B1.
Immunogen
Recombinant protein corresponding to human HSP90B1.
Host
Mouse
Reactivity
Chicken, Human, Rabbit
Specificity
Detects 90KDa proteins corresponding to the molecular mass of Hsp90beta. Identical to human (Beta-Specific), rabbit (Beta-Specific), chicken (Alpha/Beta).
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of heat shock HeLa lysate with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618).Western Blot (Cell lysate)
Western blot analysis form cell lines extracts with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618).Immunohistochemistry
Immunochemical staining of human colon cancer with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618) at 100,000 fold dilution.Immunofluorescence
Immunofluorescence staining of mouse colon (A) and human colon cancer (B) with HSP90B1 monoclonal antibody, clone H9010 (Cat # MAB6618) at 100,000 fold dilution.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HSP90B1
Entrez GeneID
7184Gene Name
HSP90B1
Gene Alias
ECGP, GP96, GRP94, TRA1
Gene Description
heat shock protein 90kDa beta (Grp94), member 1
Omim ID
191175Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 is an endoplasmic reticulum HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM
Other Designations
Tumor rejection antigen-1 (gp96)|endothelial cell (HBMEC) glycoprotein|glucose regulated protein, 94 kDa|heat shock protein 90kDa beta, member 1|tumor rejection antigen (gp96) 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
Neckers L.
Trends in Molecular Medicine 2002 Apr; 8(4 Suppl):S55.
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Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome.
Loo MA, Jensen TJ, Cui L, Hou Y, Chang XB, Riordan JR.
The EMBO Journal 1998 Dec; 17(23):6879.
Application：IP, WB-Ce, Mouse, BHK cells.
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Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes.
Barent RL, Nair SC, Carr DC, Ruan Y, Rimerman RA, Fulton J, Zhang Y, Smith DF.
Molecular Endocrinology 1998 Mar; 12(3):342.
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Hsp90 inhibitors as novel cancer chemotherapeutic agents.
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