Mouse monoclonal antibody raised against native COL2A1.
Native purified human COL2A1.
This antibody reacts specifically with human costal cartilage type II collagen.
Western Blot (2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-10 ug/mL) Immunohistochemistry (Frozen sections) (1-10 ug/mL) The optimal working dilution should be determined by the end user.
In 100 mM sodium phosphate buffer, pH 7.0 (1% protease-free BSA)
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq
OTTHUMP00000195063,cartilage collagen,chondrocalcin,collagen II, alpha-1 polypeptide