Sema7a monoclonal antibody, clone SKK-7
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of Sema7a.
Immunogen
A synthetic peptide corresponding to extracellular domain of mouse Sema7a.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
ELISA (1.0-10 ug/mL)
Flow Cyt (50 ng/mL)
Immunoprecipitation (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2% Block Ace)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — Sema7a
Entrez GeneID
20361Gene Name
Sema7a
Gene Alias
2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal
Gene Description
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Gene Ontology
HyperlinkGene Summary
sema domain
Other Designations
H-Sema K1|Semaphorin K1|semaphorin 7A
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Publication Reference
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Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.
Kinehara Y, Nagatomo I, Koyama S, Ito D, Nojima S, Kurebayashi R, Nakanishi Y, Suga Y, Nishijima-Futami Y, Osa A, Nakatani T, Kato Y, Nishide M, Hayama Y, Higashiguchi M, Morimura O, Miyake K, Kang S, Minami T, Hirata H, Iwahori K, Takimoto T, Takamatsu H, Takeda Y, Hosen N, Hoshino S, Shintani Y, Okumura M, Kumagai T, Nishino K, Imamura F, Nakatsuka SI, Kijima T, Kida H, Kumanogoh A.
JCI Insight 2018 Dec; 3(24):123093.
Application：IHC-P, Human, Human lung adenocarcinoma.
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Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.
Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H.
Nature 2007 Apr; 446(7136):680.
Application：IF, Mouse, Mouse bone-marrow-derived macrophages.
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Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.
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