ENPP3 monoclonal antibody, clone NP4D6 (PE)
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More Files
- More Functions
Flow Cytometry
Surface staining of human basophils in allergen-stimulated whole blood (CD203cpos/ SSClow) by ENPP3 monoclonal antibody, clone NP4D6 (PE) (Cat # MAB6498).
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Specification
Product Description
Mouse monoclonal antibody raised against native ENPP3.
Immunogen
Native purified from HEK293 cells transfected with human ENPP3.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with CD203C, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human basophils in allergen-stimulated whole blood (CD203cpos/ SSClow) by ENPP3 monoclonal antibody, clone NP4D6 (PE) (Cat # MAB6498). -
Gene Info — ENPP3
Entrez GeneID
5169Gene Name
ENPP3
Gene Alias
B10, CD203c, NPP3, PD-IBETA, PDNP3
Gene Description
ectonucleotide pyrophosphatase/phosphodiesterase 3
Omim ID
602182Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq
Other Designations
OTTHUMP00000040272|dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)|dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3)|gp130RB13-6|phosphodiesterase I/nucleotide pyrophosphatase 3|phosphodiesterase-I beta
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Interactome
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Pathway
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Disease
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Publication Reference
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Hymenoptera-venom-induced upregulation of the basophil activation marker ecto-nucleotide pyrophosphatase/phosphodiesterase 3 in sensitized individuals.
Platz IJ, Binder M, Marxer A, Lischka G, Valent P, Buhring HJ.
International Archives of Allergy and Immunology 2001 Dec; 126(4):335.
Application：Flow Cyt, Human, Basophils, Whole blood cells.
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The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.
Bühring HJ, Seiffert M, Giesert C, Marxer A, Kanz L, Valent P, Sano K.
Blood 2001 May; 97(10):3303.
Application：Flow Cyt, Human, HEK 293 cells.
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The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors.
Buhring HJ, Simmons PJ, Pudney M, Muller R, Jarrossay D, van Agthoven A, Willheim M, Brugger W, Valent P, Kanz L.
Blood 1999 Oct; 94(7):2343.
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Hymenoptera-venom-induced upregulation of the basophil activation marker ecto-nucleotide pyrophosphatase/phosphodiesterase 3 in sensitized individuals.
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