This antibody ecognizes extracellular domain of glutamate carboxy peptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 KDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is animportant prostate tumour marker.
Flow Cytometry (1:200) The optimal working dilution should be determined by the end user.
In PBS (0.2% BSA, 0.09% sodium azide)
Store in the dark at 4°C. Do not freeze. Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Flow cytometry analysis of FOLH1 by various monoclonal antibodies (GCP-01, GCP-02, GCP-04, GCP-05) on LNCaP cell line. Legend : green column - 1 ug/mL , LNCaP cell line. blue column - 5 ug/mL , LNCaP cell line. yellow column - negative cell line.
Flow cytometry analysis of FOLH1 using FOLH1 monoclonal antibody, clone GCP-05 (Cat # MAB3611) and FOLH1 monoclonal antibody, clone GCP-05 (PE) (Cat # MAB6477) on LNCaP cell line (positive, green) and HeLa cells (negative, blue).
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq
N-acetylated alpha-linked acidic dipeptidase 1,cell growth-inhibiting protein 27,folate hydrolase 1,folylpoly-gamma-glutamate carboxypeptidase,glutamate carboxylase II,glutamate carboxypeptidase II,membrane glutamate carboxypeptidase,prostate specific mem