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Last updated: 2016/11/27
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PRNP monoclonal antibody, clone EM-20

  • Catalog # : MAB6472
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant PRNP.
  • Immunogen:
  • Recombinant protein corresponding to human PRNP.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human prion protein (PrP). Diglycosylated form of PrP has ~40 KDa, monoglycosylated form ~30 KDa, and nonglycosylated form ~19-21 KDa. This antibody is suitable for discrimination between normal cellular prion protein (PrPc) and its conformationally changed form (PrPSc) prionprotein.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Western Blot (0.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western Blotting analysis of Creutzfeld-Jakob disease (CJD) negative (Lane 1, 2) and CJD positive (Lane 3, 4) human brain material using PRNP monoclonal antibody, clone EM-20 (Cat # MAB6472). CJD positive patient has proteinase K resistent prion protein.
    Lane 1, 4 : Samples with proteinase K treatment Lane 2, 3 : Samples without proteinase K treatment.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5621
  • Gene Name:
  • PRNP
  • Gene Alias:
  • ASCR,CD230,CJD,GSS,MGC26679,PRIP,PrP,PrP27-30,PrP33-35C,PrPc,prion
  • Gene Description:
  • prion protein
  • Gene Summary:
  • The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
  • Other Designations:
  • CD230 antigen,OTTHUMP00000030162,OTTHUMP00000030163,major prion protein,p27-30,prion protein PrP,prion-related protein
  • Gene Pathway
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