Products

Western Blot (Transfected lysate)

Immunostaining of SMARCA4 by SMARCA4 monoclonal antibody, clone BRG-01 (Cat # MAB6460).
A - SMARCA4-negative SW-13 cells were transfected with SMARCA4-expression plasmid and analysed by Western blotting for SMARCA4 expression.
B - HEK293 cytoplasmic (cyt) and nuclear (nuc) lysates were analysed by Western blotting for SMARCA4 presence.

Entrez GeneID

6597

Gene Name

SMARCA4

Gene Alias

BAF190, BRG1, FLJ39786, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2, hSNF2b

Gene Description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Omim ID

603254

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

ATP-dependent helicase SMARCA4|BRM/SWI2-related gene 1|SNF2-like 4|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4|brahma protein-like 1|global transcription activator homologous sequence|homeotic gene regulator|mitotic growth