SMARCA4 monoclonal antibody, clone BRG-01
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant SMARCA4.
Immunogen
Recombinant GST fusion protein corresponding to C-terminus 242 amino acids of human SMARCA4.
Host
Mouse
Theoretical MW (kDa)
205
Reactivity
Human
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Immunostaining of SMARCA4 by SMARCA4 monoclonal antibody, clone BRG-01 (Cat # MAB6460).
A - SMARCA4-negative SW-13 cells were transfected with SMARCA4-expression plasmid and analysed by Western blotting for SMARCA4 expression.
B - HEK293 cytoplasmic (cyt) and nuclear (nuc) lysates were analysed by Western blotting for SMARCA4 presence. -
Gene Info — SMARCA4
Entrez GeneID
6597Gene Name
SMARCA4
Gene Alias
BAF190, BRG1, FLJ39786, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2, hSNF2b
Gene Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Omim ID
603254Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ATP-dependent helicase SMARCA4|BRM/SWI2-related gene 1|SNF2-like 4|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4|brahma protein-like 1|global transcription activator homologous sequence|homeotic gene regulator|mitotic growth
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Interactome
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Disease
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Publication Reference
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The BRG1 transcriptional coregulator.
Trotter KW, Archer TK.
Nuclear Receptor Signaling 2008 Feb; 6:e004.
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The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.
Griffin CT, Brennan J, Magnuson T.
Development 2008 Feb; 135(3):493.
Application:ChIP, Mouse, Mouse erythrocytes.
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Brg1 chromatin remodeling factor is involved in cell growth arrest, apoptosis and senescence of rat mesenchymal stem cells.
Napolitano MA, Cipollaro M, Cascino A, Melone MA, Giordano A, Galderisi U.
Journal of Cell Science 2007 Aug; 120(Pt 16):2904.
Application:WB-Ce, Rat, Mesenchymal stem cells.
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The BRG1 transcriptional coregulator.
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