HSP90AB1 monoclonal antibody, clone MBH90B
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of HSP90AB1.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human HSP90AB1.
Sequence
EEVHHGEEEVEC
Host
Mouse
Reactivity
Bovine, Human, Mouse
Specificity
This antibody recognizes the EEVHHG epitope within the N-terminal part of Hsp90b, an ubiquitously expressed protein with calculated MW of 83.3 KDa, however, migrating as a 90 KDa band under reducing SDS-PAGE conditions.
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunocytochemistry (1 ug/mL)
Western Blot (1 ug/mL)
Immunoprecipitation (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blotting analysis of HSP90AB1 monoclonal antibody, clone MBH90B (Cat # MAB6458) reactivity with various cell lines and recombinant HSP90alpha and HSP90beta protein.Immunocytochemistry
Immunoprecipitation
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Gene Info — HSP90AB1
Entrez GeneID
3326Gene Name
HSP90AB1
Gene Alias
D6S182, FLJ26984, HSP90-BETA, HSP90B, HSPC2, HSPCB
Gene Description
heat shock protein 90kDa alpha (cytosolic), class B member 1
Omim ID
140572Gene Ontology
HyperlinkGene Summary
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1 (MIM 140571), an inducible form, and HSP90AB1, a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM
Other Designations
OTTHUMP00000016517|OTTHUMP00000016518|OTTHUMP00000016519|OTTHUMP00000039869|heat shock 90kD protein 1, beta|heat shock 90kDa protein 1, beta|heat shock protein beta
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Interactome
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Pathway
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Publication Reference
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The Hsp90 molecular chaperone: an open and shut case for treatment.
Pearl LH, Prodromou C, Workman P.
The Biochemical Journal 2008 Mar; 410(3):439.
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Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol.
Millson SH, Truman AW, Racz A, Hu B, Panaretou B, Nuttall J, Mollapour M, Soti C, Piper PW.
The FEBS Journal 2007 Sep; 274(17):4453.
Application:WB, Yeast, Yeast.
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Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis.
Hooven TA, Yamamoto Y, Jeffery WR.
The International Journal of Developmental Biology 2004 Oct; 48(8-9):731.
Application:ISH, Fish, Embryos.
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The Hsp90 molecular chaperone: an open and shut case for treatment.
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