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Last updated: 2016/10/16
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ITGA2B/ITGB3 monoclonal antibody, clone 8

  • Catalog # : MAB6393
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against ITGA2B/ITGB3.
  • Immunogen:
  • Native from human platelets suspension.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Under reducing conditions this antibody will bind against the human ITGA2B/ITGB3 complex.
  • Form:
  • Lyophilized
  • Isotype:
  • IgG2a, kappa
  • Recommend Usage:
  • Western Blot (10-20 ug/mL)
    ELISA (100ul of 108 washed platelets)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 10 mM PBS, pH 7.2
  • Storage Instruction:
  • Store at -20°C.
    Aliquot after reconstitution to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 3674
  • Gene Name:
  • ITGA2B
  • Gene Alias:
  • Gene Description:
  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
  • Gene Summary:
  • ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
  • Other Designations:
  • integrin alpha 2b,platelet fibrinogen receptor, alpha subunit,platelet-specific antigen BAK
  • Gene Information
  • Entrez GeneID:
  • 3690
  • Gene Name:
  • ITGB3
  • Gene Alias:
  • CD61,GP3A,GPIIIa
  • Gene Description:
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • Gene Summary:
  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq
  • Other Designations:
  • integrin beta chain, beta 3,platelet glycoprotein IIIa
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