CD55 monoclonal antibody, clone 143-30
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Specification
Product Description
Mouse monoclonal antibody raised against CD55.
Immunogen
PHA activated human PBMC.
Host
Mouse
Reactivity
Human
Specificity
human CD55.
Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (1 ug/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Flow Cytometry
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Gene Info — CD55
Entrez GeneID
1604Gene Name
CD55
Gene Alias
CR, CROM, DAF, TC
Gene Description
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Omim ID
125240Gene Ontology
HyperlinkGene Summary
This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq
Other Designations
CD55 antigen|decay accelerating factor for complement
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Interactome
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Pathway
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Disease
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Publication Reference
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Control of the complement system.
M K Liszewski, T C Farries, D M Lublin, I A Rooney, J P Atkinson.
Advances in Immunology 1996 Jan; 61:201.
Application:Flow Cyt, Human, Human mammalian cells.
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Preferential expression of the complement regulatory protein decay accelerating factor at the fetomaternal interface during human pregnancy.
Holmes CH, Simpson KL, Wainwright SD, Tate CG, Houlihan JM, Sawyer IH, Rogers IP, Spring FA, Anstee DJ, Tanner MJ.
Journal of Immunology 1990 Apr; 144(8):3099.
Application:IEM, IHC-Fr, WB-Ti, Human, Human fetal liver, Human placenta, Human red cells.
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Decay-accelerating factor: biochemistry, molecular biology, and function.
Lublin DM, Atkinson JP.
Annual Review of Immunology 1989 Jan; 7:35.
Application:Blocking, IP, WB-Ce, Human, HL-60 cells, Mammalian cells.
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Control of the complement system.
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