ITGB3 monoclonal antibody, clone PM6/13
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGB3.
Immunogen
Native purified human platelet plasma membrane.
Host
Mouse
Reactivity
Human
Specificity
human CD61.
Form
Liquid
Isotype
IgG1
Recommend Usage
Flow Cytometry (1 ug/106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — ITGB3
Entrez GeneID
3690Gene Name
ITGB3
Gene Alias
CD61, GP3A, GPIIIa
Gene Description
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Omim ID
173470Gene Ontology
HyperlinkGene Summary
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin beta chain, beta 3|platelet glycoprotein IIIa
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Interactome
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Pathway
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Disease
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Publication Reference
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Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.
Bray PF.
Thromb Haemost 1994 Aug; 72(4):492.
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The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor.
Davies J, Warwick J, Totty N, Philp R, Helfrich M, Horton M.
The Journal of Cell Biology 1989 Oct; 109(4 Pt 1):1817.
Application:IF, IP, IHC-Fr, IHC-P, WB-Ce, WB-Ti, WB-Tr, Human, Monkey, Human osteoclastoma, HUVECs, Purified proteins, Vero cells.
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Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.
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