Sialosyl-Tn antigen monoclonal antibody, clone STn 218
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Specification
Product Description
Mouse monoclonal antibody raised against Sialosyl-Tn antigen.
Immunogen
Ovine submaxillary mucin (OSM).
Host
Mouse
Reactivity
Human, Sheep
Specificity
This antibody stains colon carcinomas and ovarian mucinous carcinomas producing apical cytoplasmic, apical membrane or luminal staining patterns. It is negative with majority of adult tissue sections.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunofluorescence
Flow Cytometry
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Publication Reference
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Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc.
Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD.
Cancer Research 2008 Mar; 68(6):1636.
Application：WB-Tr, Human, LSC, LS174T cells.
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Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.
Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA.
Cancer Letters 2007 May; 249(2):157.
Application：Func, WB, Human, MKN45, MST6-I, MST6-II cells.
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Monoclonal antibody directed against colon cancer mucin has high specificity for malignancy.
Siddiki B, Ho JJ, Huang J, Byrd JC, Lau E, Yuan M, Kim YS.
International Journal of Cancer 1993 May; 54(3):467.
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Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc.
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